Gene information
Official symbol CXCL12
Official full name C-X-C motif chemokine ligand 12
Gene type protein-coding gene
Chromosome10q11.21
Alias symbolSCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1
Previous symbolSDF1A; SDF1B; SDF1
Gene familyChemokine ligands
Resources
Entrez Gene 6387
HGNC HGNC:10672
Ensembl ENSG00000107562
Vega OTTHUMG00000018054
UCSC uc001jbi.4
GO terms: 175 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001764 neuron migration GO Biological Processes -3.12579181 7 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002686 negative regulation of leukocyte migration GO Biological Processes -7.70467721 14 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0002691 regulation of cellular extravasation GO Biological Processes -7.79276545 8 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0006874 cellular calcium ion homeostasis GO Biological Processes -8.17100062 15 More
GO:0006875 cellular metal ion homeostasis GO Biological Processes -10.3879696 23 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007411 axon guidance GO Biological Processes -2.45312404 19 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007626 locomotory behavior GO Biological Processes -5.45844211 23 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008344 adult locomotory behavior GO Biological Processes -2.34507176 9 More
GO:0008361 regulation of cell size GO Biological Processes -4.6524989 21 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009408 response to heat GO Biological Processes -9.27499209 13 More
GO:0009581 detection of external stimulus GO Biological Processes -2.05740021 12 More
GO:0009582 detection of abiotic stimulus GO Biological Processes -2.39356289 13 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0016048 detection of temperature stimulus GO Biological Processes -2.54763391 5 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0021537 telencephalon development GO Biological Processes -6.21909725 29 More
GO:0021885 forebrain cell migration GO Biological Processes -5.92071483 13 More
GO:0022029 telencephalon cell migration GO Biological Processes -5.36863544 12 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030003 cellular cation homeostasis GO Biological Processes -9.22969208 24 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030516 regulation of axon extension GO Biological Processes -2.29650667 5 More
GO:0030534 adult behavior GO Biological Processes -6.59104580 21 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031100 animal organ regeneration GO Biological Processes -17.1438387 17 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0032989 cellular component morphogenesis GO Biological Processes -4.92421328 47 More
GO:0033605 positive regulation of catecholamine secretion GO Biological Processes -3.89921208 5 More
GO:0033622 integrin activation GO Biological Processes -5.24494293 4 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0045666 positive regulation of neuron differentiation GO Biological Processes -4.58725293 14 More
GO:0045773 positive regulation of axon extension GO Biological Processes -2.96833359 7 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0050433 regulation of catecholamine secretion GO Biological Processes -6.37680507 13 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050770 regulation of axonogenesis GO Biological Processes -3.56457741 17 More
GO:0050772 positive regulation of axonogenesis GO Biological Processes -1.81127841 8 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0050926 regulation of positive chemotaxis GO Biological Processes -15.5115450 16 More
GO:0050927 positive regulation of positive chemotaxis GO Biological Processes -14.3403642 15 More
GO:0050930 induction of positive chemotaxis GO Biological Processes -11.6499260 8 More
GO:0050951 sensory perception of temperature stimulus GO Biological Processes -3.21663541 6 More
GO:0050954 sensory perception of mechanical stimulus GO Biological Processes -4.15913068 20 More
GO:0050961 detection of temperature stimulus involved in sensory perception GO Biological Processes -3.03478521 5 More
GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO Biological Processes -3.41433421 5 More
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain GO Biological Processes -4.75202065 4 More
GO:0050974 detection of mechanical stimulus involved in sensory perception GO Biological Processes -3.21772170 4 More
GO:0050982 detection of mechanical stimulus GO Biological Processes -3.60984508 9 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051606 detection of stimulus GO Biological Processes -2.56190637 17 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0051952 regulation of amine transport GO Biological Processes -10.5179624 22 More
GO:0051954 positive regulation of amine transport GO Biological Processes -5.35296451 10 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061387 regulation of extent of cell growth GO Biological Processes -3.21598264 13 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0062149 detection of stimulus involved in sensory perception of pain GO Biological Processes -4.25041921 7 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0072503 cellular divalent inorganic cation homeostasis GO Biological Processes -7.40235615 16 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090025 regulation of monocyte chemotaxis GO Biological Processes -10.2459261 9 More
GO:0090026 positive regulation of monocyte chemotaxis GO Biological Processes -11.8198427 9 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090279 regulation of calcium ion import GO Biological Processes -9.31154255 13 More
GO:0090280 positive regulation of calcium ion import GO Biological Processes -7.46129980 6 More
GO:0097485 neuron projection guidance GO Biological Processes -2.79075716 20 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO Biological Processes -3.88152512 5 More
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO Biological Processes -4.39105986 5 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903236 regulation of leukocyte tethering or rolling GO Biological Processes -6.04894404 5 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell GO Biological Processes -9.55155535 14 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000106 regulation of leukocyte apoptotic process GO Biological Processes -11.3593886 22 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000401 regulation of lymphocyte migration GO Biological Processes -4.96687132 7 More
GO:2000404 regulation of T cell migration GO Biological Processes -2.70494750 4 More
GO:2000406 positive regulation of T cell migration GO Biological Processes -3.32372992 4 More
GO:2001020 regulation of response to DNA damage stimulus GO Biological Processes -1.68933987 9 More
GO:2001021 negative regulation of response to DNA damage stimulus GO Biological Processes -2.34961425 5 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001242 regulation of intrinsic apoptotic signaling pathway GO Biological Processes -16.0885267 23 More
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO Biological Processes -12.4318822 16 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04670 Leukocyte transendothelial migration KEGG Pathway -6.49203386 11 More
hsa04672 Intestinal immune network for IgA production KEGG Pathway -7.87779205 9 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
Drug-Gene interaction
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Related drugs: 7 records
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
stromal cell-derived factor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Mehta NN et al. Eur Heart J. 2014
NM_199168.4:c.801G>A genomics myocardial infarction[diagnosis] myocardial infarction Luan B et al. Mol Biol Rep. 2056
NC_000010.11:g.44258419A>G genomics myocardial infarction[diagnosis] myocardial infarction Qi L et al. Circulation. 2011
NC_000010.11:g.44280376C>T genomics myocardial infarction[diagnosis] myocardial infarction Wang Y et al. PLoS One. 2014
NM_199168.4:c.801G>A genomics myocardial infarction[diagnosis] myocardial infarction Borghini A et al. J Cardiovasc Med (Hagerstown). 2014
NM_199168.4:c.801G>A genomics myocardial infarction[diagnosis] myocardial infarction Mansoori Y et al. Genet Test Mol Biomarkers. 2017
stromal cell-derived factor 1 proteomics adverse events[prognosis (bad)] acute myocardial infarction Fortunato O et al. Cardiovasc Res. 2013
stromal cell-derived factor 1 proteomics recurrent cardiac events[prognosis (bad)] old myocardial infarction Matsuoka S et al. J Cardiol. 2017
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